PDRN the latest skincare ingredient everyone is talking about

 

PDRN (polydeoxyribonucleotide) is a regenerative DNA fragment primarily sourced from the sperm of salmon or trout. Although it may seem like a recent innovation, it has been utilized since the 1990s as a pharmaceutical solution for tissue repair, including the treatment of burns and tendon injuries. This is due to PDRN's high biocompatibility with human DNA, which allows it to promote collagen production, enhance skin elasticity, decrease inflammation, and accelerate wound healing. In recent years, it has gained immense popularity in South Korean aesthetic clinics for its skin-enhancing benefits and its ability to achieve the coveted "glass skin" appearance.

 

 

 

Promotes Skin Healing: PDRN activates particular cellular receptors that enhance the healing process, improve tissue regeneration, and fortify the outer moisture barrier.

 

Enhances Collagen & Elasticity: It activates fibroblasts (the cells responsible for skin repair) to promote the natural synthesis of collagen and elastin, which aids in reducing fine lines and tightening the skin's appearance.

 

Enhances Hydration & Radiance: Topical treatments attract and restore moisture, resulting in a plump, dewy, and smooth look for dull or fatigued skin.

 

Fades Pigmentation: Studies suggest that it may help soothe inflammation and prevent excessive melanin production, thereby diminishing acne scars, sun spots, and redness.

 

In contrast to aggressive exfoliating acids or potent retinoids, PDRN operates gently from the inside and is suitable for sensitive or post-treatment skin types.

 

 

 

Ideal if you have  dry, dehydrated, sensitive, or compromised skin, PDRN is an excellent choice. It effectively aids in barrier recovery, alleviates irritation, and addresses early signs of ageing, such as fine lines and diminished elasticity. Additionally, its regenerative and anti-inflammatory benefits make it ideal for those recovering from more invasive aesthetic procedures, including microneedling, laser treatments, and chemical peels.

 

 

If you are seeking a PDRN cream or serum, Andrea suggests considering the following: "A clearly stated source of PDRN, its concentration, and molecular profile." If the concentration is not provided, it may be too low to yield any significant results, and a lower molecular profile is typically preferred for better absorption.

 

Additionally, Andrea advises choosing products that have undergone human clinical studies of the final formulation, along with a comprehensive ingredient list. "Good tolerability is far more crucial than marketing assertions," she concludes.

 

 

Marini Reboot is among the pioneering PDRN solutions available in the professional market, formulated with a high concentration of salmon-derived PDRN (3%)  aimed at skin regeneration. It incorporates advanced rejuvenation and prejuvenation technologies to promote overall skin longevity.

 

The regenerative capabilities of PDRN enhance collagen and elastin production, facilitate barrier repair, and encourage cellular renewal. This supports the skin's inherent repair mechanisms, helping it recover from daily stressors, sun exposure, ageing, aesthetic procedures, and other factors.

 

Through the process of regenerative repair and renewal, PDRN contributes to making the skin smoother, stronger, and more resilient over time, thereby enhancing overall skin quality instead of merely masking the signs of aging. The additional rejuvenation and prejuvenation properties of squalane, sodium hyaluronate, ceramide NP, Palmitoyl Pentapeptide-4, and various botanical extracts further improve visible wrinkle reduction and structural support, providing multi-layered, long-lasting hydration, barrier repair, and calming, supportive, and protective technologies.

 

In a clinical study lasting three months, led by Dr. Zoe Draelos, the Marini Reboot® PDRN Face Serum exhibited notable advancements in essential indicators of skin health. The findings revealed a 74% increase in skin hydration and a 27% decrease in transepidermal water loss (indicating an improved skin barrier), along with reduced erythema (signifying enhanced recovery), and a significant improvement in texture, radiance, elasticity, and other aspects as assessed by physicians (indicating enhanced skin regeneration). Furthermore, 100% of participants reported improved hydration and skin smoothness.

 

 

Injectable PDRN provides high concentrations directly to the deep dermis during clinical treatments, whereas Marini Reboot™ is designed for everyday topical application. It features optimized, low-molecular-weight PDRN fragments along with penetration-boosting peptides and hyaluronic acid, ensuring ongoing regenerative signaling daily without the need for needles, recovery time, or clinical discomfort.

 

 

A lightweight, clinically advanced serum designed to visibly reduce redness, enhance overall skin clarity, and fortify the skin's moisture barrier within just 1 hour*. Infused with biotech-derived PDRN, soothing botanicals, and hyaluronic acid, it provides enduring hydration while promoting healthier, more resilient skin.

 

Experience a cutting-edge corrective treatment aimed at visibly diminishing redness, enhancing skin clarity, and reinforcing the skin's natural moisture barrier.

 

Formulated with innovative biotech-derived PDRN, obtained from Lactobacillus sakei instead of animal sources, this next-generation serum alleviates visible irritation while aiding in barrier recovery for healthier, more resilient skin. It features a specialized blend of 8% phyto-botanicals, including thyme, olive leaf, and cucumber extracts, along with calming Tripeptide-8, delivering immediate relief to stressed, redness-prone, and blemish-prone skin.

 

A deeply hydrating combination of hyaluronic acid and glycerin offers up to 48 hours of hydration*, while ectoin strengthens the skin's protective barrier against daily environmental stressors.

 

Clinically tested across all skin tones and suitable for sensitive skin, this lightweight serum is appropriate for all skin types, especially those that are sensitive, redness-prone, and blemish-prone, helping to restore balance for a smoother, clearer, and more radiant complexion.